Gene

NCOA4

Species
Homo sapiens
Symbol
NCOA4
Name
nuclear receptor coactivator 4
Synonyms
  • 70 kDa androgen receptor coactivator
  • 70 kDa AR-activator
Biotype
protein coding gene
Automated Description
Predicted to enable transcription coactivator activity. Acts upstream of or within protein targeting to lysosome. Located in autolysosome. Biomarker of invasive ductal carcinoma; ovarian carcinoma; polycystic ovary syndrome; and prostate cancer.
RGD Description
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR17085
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
46.010M46.015M46.020M46.025M46.030M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

55 interactor genes based on 104 annotations
NCOA4 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
AKT1Homo sapiens
protein
  • two hybrid
PMID:18624398
protein
ARHomo sapiens
protein
  • two hybrid
PMID:9636157
protein
ARHomo sapiens
protein
  • two hybrid
PMID:11404460
protein
ARHomo sapiens
protein
  • pull down
PMID:9892017
protein
ARHomo sapiens
protein
  • two hybrid
PMID:10318905
protein
ARHomo sapiens
protein
  • pull down
PMID:11818501
protein
ARHomo sapiens
protein
  • two hybrid
PMID:10517667
protein
ARHomo sapiens
protein
  • pull down
PMID:10517667
protein
ARHomo sapiens
protein
  • two hybrid
PMID:9892017
protein
ARHomo sapiens
protein
  • two hybrid
PMID:8643607
Showing 1 - 10 of 103 rows
per page

Genetic Interactions