Gene

ABL2

Species
Homo sapiens
Symbol
ABL2
Name
ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms
  • Abelson murine leukemia viral (v-abl) oncogene homolog 2
  • abelson murine leukemia viral oncogene homolog 2
Biotype
protein coding gene
Automated Description
Enables metal ion binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Involved in several processes, including cellular response to retinoic acid; peptidyl-tyrosine phosphorylation; and positive regulation of neuron projection development. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Predicted to be located in dendritic spine; lamellipodium; and phagocytic cup. Predicted to be active in glutamatergic synapse; plasma membrane; and postsynapse.
RGD Description
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24418
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
179.10M179.12M179.14M179.16M179.18M179.20M179.22M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions