Enables metal ion binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Involved in several processes, including cellular response to retinoic acid; peptidyl-tyrosine phosphorylation; and positive regulation of neuron projection development. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Predicted to be located in dendritic spine; lamellipodium; and phagocytic cup. Predicted to be active in glutamatergic synapse; plasma membrane; and postsynapse.
RGD Description
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]