Gene

NMT1

Species
Homo sapiens
Symbol
NMT1
Name
N-myristoyltransferase 1
Synonyms
  • alternative, short form NMT-S
  • glycylpeptide N-tetradecanoyltransferase 1
Biotype
protein coding gene
Automated Description
Enables glycylpeptide N-tetradecanoyltransferase activity and peptidyl-lysine N6-myristoyltransferase activity. Involved in N-terminal peptidyl-glycine N-myristoylation; ketone metabolic process; and protein localization to membrane. Located in cytosol and plasma membrane.
RGD Description
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11377
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
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44.96M44.98M45.00M45.02M45.04M45.06M45.08M45.10M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions