Version: 8.0.0
Date: Tue Jan 28 2025
NRG1
Homo sapiensHGNC:7997
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

NRG1

Species
Homo sapiens
Symbol
NRG1
Name
neuregulin 1
Synonyms
  • acetylcholine receptor-inducing activity
  • ARIA
Biotype
protein coding gene
Automated Description
Enables protein tyrosine kinase activator activity; signaling receptor binding activity; and transcription coregulator activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; heart development; and positive regulation of protein phosphorylation. Acts upstream of or within negative regulation of DNA-templated transcription. Located in apical plasma membrane and nucleoplasm. Is active in extracellular space and glutamatergic synapse. Implicated in several diseases, including cannabis dependence; cerebral malaria; cerebrovascular disease (multiple); psychotic disorder (multiple); and substance abuse (multiple). Biomarker of Alzheimer's disease; cannabis abuse; hepatocellular carcinoma; major depressive disorder; and ovarian cancer.
RGD Description
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11100
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          NRG1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            NRG1 role
            NRG1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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