Enables several functions, including ATPase activator activity; ATPase binding activity; and P-type sodium:potassium-exchanging transporter activity. Involved in several processes, including intracellular monoatomic cation homeostasis; positive regulation of cation transmembrane transport; and protein stabilization. Located in several cellular components, including T-tubule; lateral plasma membrane; and sperm flagellum. Part of sodium:potassium-exchanging ATPase complex. Implicated in essential hypertension.
RGD Description
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]