Gene

ATP1B1

Species
Homo sapiens
Symbol
ATP1B1
Name
ATPase Na+/K+ transporting subunit beta 1
Synonyms
  • adenosinetriphosphatase
  • ATP1B
Biotype
protein coding gene
Automated Description
Enables several functions, including ATPase activator activity; ATPase binding activity; and P-type sodium:potassium-exchanging transporter activity. Involved in several processes, including intracellular monoatomic cation homeostasis; positive regulation of cation transmembrane transport; and protein stabilization. Located in several cellular components, including T-tubule; lateral plasma membrane; and sperm flagellum. Part of sodium:potassium-exchanging ATPase complex. Implicated in essential hypertension.
RGD Description
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11523
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
169.12M169.14M169.16M169.18M169.20M169.22M169.24M169.26M169.28M169.30M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions