Enables SH2 domain binding activity; signaling receptor complex adaptor activity; and ubiquitin binding activity. Involved in several processes, including microtubule organizing center organization; positive regulation of canonical NF-kappaB signal transduction; and regulation of cell cycle process. Located in several cellular components, including Flemming body; microtubule cytoskeleton; and nucleus. Part of nuclear pore and ribonucleoprotein complex. Implicated in primary biliary cholangitis and striatonigral degeneration.
RGD Description
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]