Gene

NUP62

Species
Homo sapiens
Symbol
NUP62
Name
nucleoporin 62
Synonyms
  • 62 kDa nucleoporin
  • DKFZp547L134
Biotype
protein coding gene
Automated Description
Enables SH2 domain binding activity; signaling receptor complex adaptor activity; and ubiquitin binding activity. Involved in several processes, including microtubule organizing center organization; positive regulation of canonical NF-kappaB signal transduction; and regulation of cell cycle process. Located in several cellular components, including Flemming body; microtubule cytoskeleton; and nucleus. Part of nuclear pore and ribonucleoprotein complex. Implicated in primary biliary cholangitis and striatonigral degeneration.
RGD Description
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12084
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
49.908M49.910M49.912M49.914M49.916M49.918M49.920M49.922M49.924M49.926M49.928M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions