Gene

ACACB

Species
Homo sapiens
Symbol
ACACB
Name
acetyl-CoA carboxylase beta
Synonyms
  • ACACbeta
  • ACC-beta
Biotype
protein coding gene
Automated Description
Enables acetyl-CoA carboxylase activity and identical protein binding activity. Involved in acetyl-CoA metabolic process and protein homotetramerization. Located in mitochondrion and nucleus.
RGD Description
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. [provided by RefSeq, Oct 2022]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45728
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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      Transgenic construct
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          ACACB molecule type
          Interactor gene
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            Genetic Interactions

            ACACB role
            ACACB genetic perturbation
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            Interactor genetic perturbation
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