Gene

PDE1C

Species
Homo sapiens
Symbol
PDE1C
Name
phosphodiesterase 1C
Synonyms
  • 3',5'-cyclic-AMP phosphodiesterase
  • 3',5'-cyclic-GMP phosphodiesterase
Biotype
protein coding gene
Automated Description
Enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Predicted to act upstream of or within response to calcium ion and sensory perception of smell. Predicted to be located in cilium and lysosome. Predicted to be active in neuronal cell body. Implicated in autosomal dominant nonsyndromic deafness 74.
RGD Description
This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11347
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            31.7M31.8M31.9M32.0M32.1M32.2M32.3M32.4M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            PDE1C molecule type
            Interactor gene
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              Genetic Interactions

              PDE1C role
              PDE1C genetic perturbation
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