Gene

PDE8B

Species
Homo sapiens
Symbol
PDE8B
Name
phosphodiesterase 8B
Synonyms
  • 3',5' cyclic nucleotide phosphodiesterase 8B
  • ADSD
Biotype
protein coding gene
Automated Description
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within several processes, including behavioral fear response; learning; and negative regulation of steroid hormone biosynthetic process. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Implicated in primary pigmented nodular adrenocortical disease 3.
RGD Description
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11347
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusPde8b10 of 10YesYes  
Rattus norvegicusPde8b10 of 10YesYes  
Xenopus tropicalispde8b4 of 9YesYes   
Danio reriopde8b10 of 10YesYes  
Drosophila melanogasterPde89 of 9YesYes   
Caenorhabditis eleganspde-67 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
PDE8A191075618 of 8  
PDE11A2101835213 of 8  
PDE10A3105133202 of 8  
PDE3B484338233 of 8  
PDE5A596734193 of 8  
PDE6B680738203 of 8  
PDE4B763443264 of 8  
PDE6A876238203 of 8  
PDE4A958643274 of 8  
PDE4D1055946274 of 8  
PDE4C1157044274 of 8  
PDE9A1262041253 of 8  
PDE3A1361839233 of 8  
PDE2A1464038232 of 8  
PDE1C1545147253 of 8  
PDE1A1640549273 of 8  
PDE7A1736552313 of 8  
PDE1B1844643272 of 8  
PDE7B1940347273 of 8  
PDE6C2032746263 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Abnormality of movement
Adrenal hyperplasia
Autosomal dominant inheritance
Bradykinesia
Brisk reflexes
Degeneration of the striatum
Dysarthria
Dysdiadochokinesis
Dysphagia
Gait disturbance
Showing 1 - 10 of 19 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
77.10M77.15M77.20M77.25M77.30M77.35M77.40M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

5 interactor genes based on 5 annotations
PDE8B molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
FOXO1Homo sapiens
protein
  • proximity labelling technology
PMID:36964488
protein
PDE8AHomo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
SNX27Homo sapiens
protein
  • affinity chromatography technology
PMID:34315543
protein
UCHL1Homo sapiens
protein
  • affinity chromatography technology
PMID:32120844
protein
XPO1Homo sapiens
protein
  • affinity chromatography technology
PMID:26673895
Showing 1 - 5 of 5 rows
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Genetic Interactions

No data available