Gene

PHF1

Species
Homo sapiens
Symbol
PHF1
Name
PHD finger protein 1
Synonyms
  • hPCl1
  • hPHF1
Biotype
protein coding gene
Automated Description
Enables several functions, including histone methyltransferase binding activity; identical protein binding activity; and transcription corepressor binding activity. Involved in DNA repair-dependent chromatin remodeling. Located in several cellular components, including ESC/E(Z) complex; centrosome; and site of double-strand break.
RGD Description
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12628
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
33.411M33.412M33.413M33.414M33.415M33.416M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions