Enables several functions, including histone methyltransferase binding activity; identical protein binding activity; and transcription corepressor binding activity. Involved in DNA repair-dependent chromatin remodeling. Located in several cellular components, including ESC/E(Z) complex; centrosome; and site of double-strand break.
RGD Description
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]