Gene

PIK3C2A

Species
Homo sapiens
Symbol
PIK3C2A
Name
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms
  • C2-containing phosphatidylinositol kinase
  • CPK
Biotype
protein coding gene
Automated Description
Enables clathrin binding activity and phosphatidylinositol kinase activity. Involved in endocytosis; positive regulation of autophagy; and positive regulation of cell migration involved in sprouting angiogenesis. Located in several cellular components, including clathrin-coated vesicle; nucleoplasm; and trans-Golgi network. Biomarker of type 2 diabetes mellitus.
RGD Description
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10048
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
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17.08M17.10M17.12M17.14M17.16M17.18M17.20M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions