Enables several functions, including ephrin receptor binding activity; phosphatidylinositol kinase activity; and protein serine kinase activity. Involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; positive regulation of intracellular signal transduction; and sphingosine-1-phosphate receptor signaling pathway. Located in cytosol and plasma membrane. Part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Implicated in autistic disorder; primary immunodeficiency disease; and swine influenza. Biomarker of pancreatic ductal adenocarcinoma.
RGD Description
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]