Gene

PIK3CG

Species
Homo sapiens
Symbol
PIK3CG
Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms
  • 1-phosphatidylinositol 3-kinase
  • IMD97
Biotype
protein coding gene
Automated Description
Enables several functions, including ephrin receptor binding activity; phosphatidylinositol kinase activity; and protein serine kinase activity. Involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; positive regulation of intracellular signal transduction; and sphingosine-1-phosphate receptor signaling pathway. Located in cytosol and plasma membrane. Part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Implicated in autistic disorder; primary immunodeficiency disease; and swine influenza. Biomarker of pancreatic ductal adenocarcinoma.
RGD Description
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10048
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
106.870M106.875M106.880M106.885M106.890M106.895M106.900M106.905M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions