Version: 8.0.0Date: Tue Jan 28 2025
Gene
PLAUR
- Species
- Homo sapiens
- Symbol
- PLAUR
- Name
- plasminogen activator, urokinase receptor
- Synonyms
- CD87
- monocyte activation antigen Mo3
- Biotype
- protein coding gene
- Automated Description
- Enables enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of release of cytochrome c from mitochondria; regulation of protein metabolic process; and regulation of signal transduction. Located in cell surface and plasma membrane. Part of protein complex involved in cell-matrix adhesion and serine-type endopeptidase complex. Implicated in rheumatoid arthritis. Biomarker of several diseases, including Lyme disease; cardiovascular system disease (multiple); end stage renal disease; hepatitis B; and melioidosis.
- RGD Description
- This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10624
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr19:43646095...43670547 - (24.45 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.