Version: 8.0.0Date: Tue Jan 28 2025
Gene
POLA1
- Species
- Homo sapiens
- Symbol
- POLA1
- Name
- DNA polymerase alpha 1, catalytic subunit
- Synonyms
- DKFZp686K1672
- DNA polymerase alpha 1 catalytic subunit
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including DNA-directed DNA polymerase activity; protein kinase binding activity; and zinc ion binding activity. Involved in DNA metabolic process and regulation of type I interferon production. Located in several cellular components, including chromatin; nuclear envelope; and nuclear lumen. Part of alpha DNA polymerase:primase complex. Implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder.
- RGD Description
- This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR45861
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- ChrX:24693873...24996986 + (303.11 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction