Gene

PPIB

Species
Homo sapiens
Symbol
PPIB
Name
peptidylprolyl isomerase B
Synonyms
  • B
  • cyclophilin b
Biotype
protein coding gene
Automated Description
Enables RNA polymerase binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including neutrophil chemotaxis; positive regulation by host of viral genome replication; and protein stabilization. Located in endoplasmic reticulum; nucleoplasm; and perinuclear region of cytoplasm. Implicated in osteogenesis imperfecta type 9.
RGD Description
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11071
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
64.156M64.157M64.158M64.159M64.160M64.161M64.162M64.163M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions