Enables thioredoxin peroxidase activity. Involved in natural killer cell activation. Acts upstream of or within hydrogen peroxide catabolic process. Located in cytoplasm and nucleus. Implicated in methylmalonic aciduria and homocystinuria type cblC.
RGD Description
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]