Version: 8.0.0
Date: Tue Jan 28 2025
PROC
Homo sapiensHGNC:9451
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

PROC

Species
Homo sapiens
Symbol
PROC
Name
protein C, inactivator of coagulation factors Va and VIIIa
Synonyms
  • activated protein C
  • anticoagulant protein C
Biotype
protein coding gene
Automated Description
Enables serine-type endopeptidase activity. Involved in several processes, including negative regulation of coagulation; negative regulation of inflammatory response; and positive regulation of establishment of endothelial barrier. Located in Golgi apparatus and endoplasmic reticulum. Implicated in several diseases, including antiphospholipid syndrome; central retinal vein occlusion; placental abruption; thrombophilia (multiple); and toxic shock syndrome. Biomarker of disseminated intravascular coagulation; myocardial infarction; osteonecrosis; pulmonary embolism; and thrombotic thrombocytopenic purpura.
RGD Description
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24278
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          PROC molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            PROC role
            PROC genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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