Gene

PSMA6

Species
Homo sapiens
Symbol
PSMA6
Name
proteasome 20S subunit alpha 6
Synonyms
  • 27 kDa prosomal protein
  • alpha-1
Biotype
protein coding gene
Automated Description
Enables NF-kappaB binding activity and RNA binding activity. Involved in positive regulation of NF-kappaB transcription factor activity and proteolysis involved in protein catabolic process. Located in nucleoplasm and ribosome. Part of proteasome core complex, alpha-subunit complex. Is active in cytoplasm and nucleus. Implicated in myocardial infarction.
RGD Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11599
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
35.280M35.285M35.290M35.295M35.300M35.305M35.310M35.315M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions