Enables NF-kappaB binding activity and RNA binding activity. Involved in positive regulation of NF-kappaB transcription factor activity and proteolysis involved in protein catabolic process. Located in nucleoplasm and ribosome. Part of proteasome core complex, alpha-subunit complex. Is active in cytoplasm and nucleus. Implicated in myocardial infarction.
RGD Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]