Version: 8.0.0Date: Tue Jan 28 2025
Gene
PTPN13
- Species
- Homo sapiens
- Symbol
- PTPN13
- Name
- protein tyrosine phosphatase non-receptor type 13
- Synonyms
- APO-1/CD95 (Fas)-associated phosphatase
- DKFZp686J1497
- Biotype
- protein coding gene
- Automated Description
- Enables phosphatidylinositol 3-kinase regulatory subunit binding activity and protein tyrosine phosphatase activity. Involved in negative regulation of protein phosphorylation; peptidyl-tyrosine dephosphorylation; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in several cellular components, including cytosol; lamellipodium; and nuclear lumen. Implicated in breast cancer; carcinoma (multiple); and colorectal cancer (multiple). Biomarker of gastric adenocarcinoma; lung adenocarcinoma; lung large cell carcinoma; lung squamous cell carcinoma; and oral squamous cell carcinoma.
- RGD Description
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR46900
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr4:86594315...86815171 + (220.86 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.