Gene

PTPRC

Species
Homo sapiens
Symbol
PTPRC
Name
protein tyrosine phosphatase receptor type C
Synonyms
  • B220
  • CD45
Biotype
protein coding gene
Automated Description
Enables several functions, including cytoskeletal protein binding activity; protein tyrosine kinase inhibitor activity; and transmembrane receptor protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of cell population proliferation; and regulation of macromolecule metabolic process. Located in bleb and external side of plasma membrane. Implicated in multiple sclerosis; primary immunodeficiency disease; and severe combined immunodeficiency.
RGD Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46957
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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    Alleles and Variants

    Allele/Variant Symbol
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
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        Models

        Model name
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          PTPRC molecule type
          Interactor gene
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          Interactor molecule type
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            Genetic Interactions

            PTPRC role
            PTPRC genetic perturbation
            Interactor gene
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            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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