Version: 8.0.0
Date: Tue Jan 28 2025
RAC1
Homo sapiensHGNC:9801
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

RAC1

Species
Homo sapiens
Symbol
RAC1
Name
Rac family small GTPase 1
Synonyms
  • cell migration-inducing gene 5 protein
  • MGC111543
Biotype
protein coding gene
Automated Description
Enables GTP binding activity; GTPase activity; and enzyme binding activity. Involved in several processes, including plasma membrane bounded cell projection assembly; positive regulation of cellular component biogenesis; and regulation of cell migration. Acts upstream of or within actin cytoskeleton organization; positive regulation of lamellipodium assembly; and ruffle organization. Located in several cellular components, including recycling endosome membrane; ruffle membrane; and trans-Golgi network. Is active in glutamatergic synapse and postsynapse. Implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Biomarker of breast cancer; colon adenoma; gastrointestinal system cancer (multiple); and pancreatic ductal adenocarcinoma.
RGD Description
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24072
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          RAC1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            RAC1 role
            RAC1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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