Gene

RAD21

Species
Homo sapiens
Symbol
RAD21
Name
RAD21 cohesin complex component
Synonyms
  • CDLS4
  • double-strand-break repair protein rad21 homolog
Biotype
protein coding gene
Automated Description
Predicted to enable chromatin binding activity and cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of sister chromatid cohesion; protein localization to chromatin; and regulation of transcription by RNA polymerase II. Located in midbody; nuclear matrix; and nucleoplasm. Part of mitotic cohesin complex. Implicated in Cornelia de Lange syndrome 4; endometrial cancer; hepatocellular carcinoma; and lung non-small cell carcinoma. Biomarker of colorectal carcinoma; hepatocellular carcinoma; and oral squamous cell carcinoma.
RGD Description
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12585
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          RAD21 molecule type
          Interactor gene
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            Genetic Interactions

            RAD21 role
            RAD21 genetic perturbation
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