calcitonin receptor-like receptor activity modifying protein 1
calcitonin-receptor-like receptor activity-modifying protein 1
Biotype
protein coding gene
Automated Description
Enables calcitonin family receptor activity; calcitonin gene-related peptide binding activity; and coreceptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of protein glycosylation; and protein localization to plasma membrane. Located in cell surface and plasma membrane. Part of CGRP receptor complex.
RGD Description
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]