Gene

RAMP1

Species
Homo sapiens
Symbol
RAMP1
Name
receptor activity modifying protein 1
Synonyms
  • calcitonin receptor-like receptor activity modifying protein 1
  • calcitonin-receptor-like receptor activity-modifying protein 1
Biotype
protein coding gene
Automated Description
Enables calcitonin family receptor activity; calcitonin gene-related peptide binding activity; and coreceptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of protein glycosylation; and protein localization to plasma membrane. Located in cell surface and plasma membrane. Part of CGRP receptor complex.
RGD Description
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14076
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
237.860M237.865M237.870M237.875M237.880M237.885M237.890M237.895M237.900M237.905M237.910M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions