Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in several processes, including Rap protein signal transduction; cellular response to cAMP; and positive regulation of integrin activation. Located in cell-cell junction; cytosol; and lipid droplet. Implicated in thrombocytopenia.
RGD Description
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]