Gene

RAP1B

Species
Homo sapiens
Symbol
RAP1B
Name
RAP1B, member of RAS oncogene family
Synonyms
  • DKFZp586H0723
  • FLJ18601
Biotype
protein coding gene
Automated Description
Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in several processes, including Rap protein signal transduction; cellular response to cAMP; and positive regulation of integrin activation. Located in cell-cell junction; cytosol; and lipid droplet. Implicated in thrombocytopenia.
RGD Description
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24070
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
68.62M68.63M68.64M68.65M68.66M68.67M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions