Version: 8.0.0
Date: Tue Jan 28 2025
Tubg1
Mus musculusMGI:101834
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Tubg1

Species
Mus musculus
Symbol
Tubg1
Name
tubulin, gamma 1
Synonyms
  • 1500010O08Rik
  • AI451582
Biotype
protein coding gene
Automated Description
Predicted to enable GTP binding activity; identical protein binding activity; and microtubule nucleator activity. Involved in meiotic spindle organization. Located in several cellular components, including condensed nuclear chromosome; microtubule cytoskeleton; and non-motile cilium. Is expressed in several structures, including central nervous system; eye; head mesenchyme; heart; and respiratory system. Used to study complex cortical dysplasia with other brain malformations 4. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to human TUBG1 (tubulin gamma 1).
MGI Description
PHENOTYPE: Homozygous null mice display embryonic lethality and growth arrest at the blastocyst stage. Heterozygosity for the p.Y92C mutation affects cerebral cortex and hippocampus development and leads to increased locomotor activity, impaired fear conditioning behavior and increased sensitivity to chemically induced seizures. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11588
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Tubg1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Tubg1 role
            Tubg1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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