Version: 8.0.0
Date: Tue Jan 28 2025
Pou3f2
Mus musculusMGI:101895
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pou3f2

Species
Mus musculus
Symbol
Pou3f2
Name
POU domain, class 3, transcription factor 2
Synonyms
  • 9430075J19Rik
  • A230098E07Rik
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of gene expression. Acts upstream of or within several processes, including epidermis development; nervous system development; and regulation of axonogenesis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including future brain; genitourinary system; nervous system; sensory organ; and thymus. Orthologous to human POU3F2 (POU class 3 homeobox 2).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in lethality by 10 days of age. Mutant animals are growth retarded, have hyperkeratotic, flaky skin, and exhibit loss of the posterior pituitary and disruption of late endocrine hypothalamic development. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11636
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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          Associated Human Diseases
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            22.4830M22.4835M22.4840M22.4845M22.4850M22.4855M22.4860M22.4865M22.4870M22.4875M22.4880M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Pou3f2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              Pou3f2 role
              Pou3f2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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