Gene

F2rl1

Species
Mus musculus
Symbol
F2rl1
Name
F2R like trypsin receptor 1
Synonyms
  • coagulation factor II (thrombin) receptor-like 1
  • G-protein coupled receptor 11
Biotype
protein coding gene
Automated Description
Enables G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and proteinase-activated receptor activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and regulation of protein secretion. Located in pseudopodium. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and skin. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1).
MGI Description
PHENOTYPE: Nullizygous mice may exhibit impaired leukocyte rolling and dendritic cell maturation, altered inflammatory response in various models of acute and chronic inflammatory disease, altered susceptibility to injury and to autoimmune disorders, and abnormal hemodynamic responses and pain thresholds. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24232
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
95.650M95.652M95.654M95.656M95.658M95.660M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions