Enables G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and proteinase-activated receptor activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and regulation of protein secretion. Located in pseudopodium. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and skin. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1).
MGI Description
PHENOTYPE: Nullizygous mice may exhibit impaired leukocyte rolling and dendritic cell maturation, altered inflammatory response in various models of acute and chronic inflammatory disease, altered susceptibility to injury and to autoimmune disorders, and abnormal hemodynamic responses and pain thresholds. [provided by MGI curators]