Version: 8.0.0Date: Tue Jan 28 2025
Gene
mt-Co1
- Species
- Mus musculus
- Symbol
- mt-Co1
- Name
- mitochondrially encoded cytochrome c oxidase I
- Synonyms
- AU018394
- AU018682
- Biotype
- protein coding gene
- Automated Description
- Enables cytochrome-c oxidase activity. Predicted to be involved in aerobic respiration; respiratory electron transport chain; and response to oxidative stress. Part of respiratory chain complex IV. Is active in mitochondrial inner membrane. Is expressed in several structures, including brain; brown fat; liver; musculature; and stomach. Orthologous to human MT-CO1 (mitochondrially encoded cytochrome c oxidase I).
- MGI Description
- PHENOTYPE: Transmitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in this gene show growth retardation, reduced COX activity in cardiac cells, increased blood lactate levels, mitochondrial myopathy, heart inflammation and edema, abnormal bloodvessel morphology, and severe cardiomyopathy. [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10422
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- ChrMT:5328...6872 + (1.54 kb)
- Assembly version
- GRCm39
- Viewer Help
Data currently unavailable; sequence viewer under construction