Version: 8.0.0
Date: Tue Jan 28 2025
Ddx4
Mus musculusMGI:102670
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ddx4

Species
Mus musculus
Symbol
Ddx4
Name
DEAD box helicase 4
Synonyms
  • AV206478
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Biotype
protein coding gene
Automated Description
Enables ATP hydrolysis activity. Involved in male meiosis I; regulatory ncRNA-mediated gene silencing; and spermatogenesis. Acts upstream of with a positive effect on transposable element silencing by piRNA-mediated heterochromatin formation. Acts upstream of or within regulation of protein localization. Located in cytoplasmic ribonucleoprotein granule; nucleus; and perinuclear region of cytoplasm. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system mesentery; aorta-gonad-mesonephros; embryo ectoderm; gonad; and gonad primordium. Orthologous to human DDX4 (DEAD-box helicase 4).
MGI Description
PHENOTYPE: Spermatogenesis is blocked in homozygous mutant mice, resulting in male infertility. Female mutant mice are fertile and do not exhibit any obvious reproductive defects. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47958
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Ddx4 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Ddx4 role
            Ddx4 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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