Gene

Reln

Species
Mus musculus
Symbol
Reln
Name
reelin
Synonyms
  • Reelen
  • reeler
Biotype
protein coding gene
Automated Description
Enables receptor ligand activity; serine-type peptidase activity; and very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; positive regulation of cell communication; and regulation of neurotransmitter receptor activity. Acts upstream of or within several processes, including nervous system development; peptidyl-tyrosine phosphorylation; and thyroid hormone metabolic process. Located in cytoplasm; dendrite; and extracellular matrix. Is active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; and familial temporal lobe epilepsy 7. Orthologous to human RELN (reelin).
MGI Description
PHENOTYPE: Homozygotes for most spontaneous or ENU-induced mutations show impaired righting responses, ataxia, tremors, and cerebellum and hippocampus abnormalities. Some mutants show postnatal or premature death and decreased body size while others have abnormal retinas or olfactory bulbs or infertility. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11841
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Relnrl/Reln+ [background:] B6.Cg-Relnrl
  • abnormal prepulse inhibition
  • abnormal short-term spatial reference memory
MGI
Relnrl/Reln+ [background:] B6C3Fe a/a-Relnrl/J
  • abnormal ventral striatum morphology
  • decreased dopaminergic neuron number
MGI
Dab1tm1Cpr/Dab1tm4Cpr Relnrl/Reln+ [background:] involves: 129/Sv * C3HeB/Fe * C57BL/6
  • abnormal cortical marginal zone morphology
  • abnormal hippocampus morphology
MGI
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+ Relnrl/Reln+ Trp73tm1(cre)Agof/Trp73+ [background:] involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
  • decreased Cajal-Retzius cell number
MGI
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+ Relnrl/Reln+ Trp73tm1(cre)Agof/Trp73+ Wnt3atm1(cre)Eag/Wnt3a+ [background:] involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
  • decreased Cajal-Retzius cell number
MGI
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+ Relnrl/Reln+ Wnt3atm1(cre)Eag/Wnt3a+ [background:] involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
  • decreased Cajal-Retzius cell number
MGI
Relnctrdel/Relnctrdel Rgs4tm1Dgen/Rgs4+ [background:] involves: 129P2/OlaHsd * A/J * C57BL/6
  • abnormal stratification in cerebral cortex
MGI
Relnem1(IMPC)Mbp/Reln+ [background:] C57BL/6N-Relnem1(IMPC)Mbp/MbpMmucd
  • abnormal lymph node morphology
  • abnormal skin morphology
MGI
Relnem1(IMPC)Mbp/Relnem1(IMPC)Mbp [background:] C57BL/6N-Relnem1(IMPC)Mbp/MbpMmucd
  • female infertility
  • male infertility
MGI
Relnm1Anu/Relnm1Anu [background:] C57BL/6JAnu-Relnm1Anu
  • decreased body size
  • impaired coordination
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
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22.10M22.15M22.20M22.25M22.30M22.35M22.40M22.45M22.50M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions