Enables receptor ligand activity; serine-type peptidase activity; and very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; positive regulation of cell communication; and regulation of neurotransmitter receptor activity. Acts upstream of or within several processes, including nervous system development; peptidyl-tyrosine phosphorylation; and thyroid hormone metabolic process. Located in cytoplasm; dendrite; and extracellular matrix. Is active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; and familial temporal lobe epilepsy 7. Orthologous to human RELN (reelin).
MGI Description
PHENOTYPE: Homozygotes for most spontaneous or ENU-induced mutations show impaired righting responses, ataxia, tremors, and cerebellum and hippocampus abnormalities. Some mutants show postnatal or premature death and decreased body size while others have abnormal retinas or olfactory bulbs or infertility. [provided by MGI curators]