Version: 8.0.0
Date: Tue Jan 28 2025
Pura
Mus musculusMGI:103079
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pura

Species
Mus musculus
Symbol
Pura
Name
purine rich element binding protein A
Synonyms
  • CAGER-1
  • Pur alpha
Biotype
protein coding gene
Automated Description
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding activity; and transcription regulator inhibitor activity. Involved in dendritic transport of messenger ribonucleoprotein complex; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including epithelial cell proliferation; lymphocyte proliferation; and negative regulation of DNA-templated transcription. Located in cytoplasm; dendrite; and neuronal cell body. Is active in glutamatergic synapse; nucleus; and postsynapse. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 31. Orthologous to human PURA (purine rich element binding protein A).
MGI Description
PHENOTYPE: Homozygous null mice are overtly normal within the first few weeks of life but later manifest severe neurological defects and die shortly after weaning. Neuroanatomical abnormalities are also observed. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12611
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            36.416M36.418M36.420M36.422M36.424M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Pura molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Pura role
              Pura genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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