Version: 8.0.0
Date: Tue Jan 28 2025
Gfi1
Mus musculusMGI:103170
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gfi1

Species
Mus musculus
Symbol
Gfi1
Name
growth factor independent 1 transcription repressor
Synonyms
  • AW495828
  • expressed sequence AW495828
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription repressor activity. Involved in cellular response to lipopolysaccharide; negative regulation of NF-kappaB transcription factor activity; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including inner ear development; mechanosensory behavior; and regulation of cell fate specification. Predicted to be located in nuclear body and nuclear matrix. Predicted to be part of transcription repressor complex. Is expressed in several structures, including aorta-gonad-mesonephros; cranial ganglion; gut epithelium; hemolymphoid system; and sensory organ. Used to study severe congenital neutropenia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; myelodysplastic syndrome; and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).
MGI Description
PHENOTYPE: Homozygotes for targeted null mutations exhibit loss of inner ear hair cells, ataxia, circling, and deafness. Mutants also show a block in granulocyte and neutrophil maturation, and are hypersensitive to endotoxin stimulation. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24404
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Gfi1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
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            Genetic Interactions

            Gfi1 role
            Gfi1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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