Gene

Rbl1

Species
Mus musculus
Symbol
Rbl1
Name
RB transcriptional corepressor like 1
Synonyms
  • AW547426
  • expressed sequence AW547426
Biotype
protein coding gene
Automated Description
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; palatal shelf; retina; and telencephalon. Used to study retinoblastoma and urinary bladder cancer. Orthologous to human RBL1 (RB transcriptional corepressor like 1).
MGI Description
PHENOTYPE: Homozygotes for targeted null mutations are viable and fertile, but may show impaired growth, myeloid hyperplasia in spleen and liver and give rise to cells with a 2X doubling time in vitro. These effects are genetic background dependent. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13742
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensRBL110 of 10YesYes  
Rattus norvegicusRbl18 of 9YesYes   
Xenopus tropicalisrbl15 of 9YesYes   
Danio reriorbl110 of 10YesYes  
Drosophila melanogasterRbf8 of 9YesYes   
Drosophila melanogasterRbf23 of 9NoYes   
Caenorhabditis eleganslin-357 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Rbl21114864488 of 9 
Rb12111140254 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal amacrine cell morphology
abnormal common myeloid progenitor cell morphology
abnormal cone electrophysiology
abnormal definitive hematopoiesis
abnormal eye development
abnormal inflammatory response
abnormal kidney morphology
abnormal muscle physiology
abnormal neuronal precursor proliferation
abnormal optic nerve morphology
Showing 1 - 10 of 46 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Rb1tm2Brn/Rb1tm2Brn Rbl1tm1Tyj/Rbl1tm1Tyj Rbl2tm2Tyj/Rbl2tm2Tyj [background:] involves: 129 * 129S2/SvPas * 129S4/SvJae
  • hematuria
  • increased urinary bladder carcinoma incidence
MGI
Rb1tm3Tyj/Rb1tm3Tyj Rbl1tm1Tyj/Rbl1tm1Tyj Rbl2tm2.1Tyj/Rbl2tm2.1Tyj [background:] involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
  • increased hepatocellular carcinoma incidence
MGI
Rb1tm3Tyj/Rb1tm3Tyj Rbl1tm1Tyj/Rbl1tm1Tyj Tg(Pax6-cre,GFP)2Pgr/0 [background:] involves: 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N
  • abnormal retina morphology
  • increased retinoblastoma incidence
MGI
E2f1tm1Meg/E2f1+ Rbl1tm1Htr/Rbl1tm1Htr Tg(Pax6-cre,GFP)2Pgr/? [background:] involves: 129 * C57BL/6 * FVB/N * NMRI
  • abnormal eye development
MGI
E2f1tm1Meg/E2f1tm1Meg Rbl1tm1Htr/Rbl1tm1Htr Tg(Pax6-cre,GFP)2Pgr/? [background:] involves: 129 * C57BL/6 * FVB/N * NMRI
  • abnormal amacrine cell morphology
  • abnormal cone electrophysiology
MGI
E2f2tm1Zubi/E2f2tm1Zubi Rbl1tm1Htr/Rbl1tm1Htr Tg(Pax6-cre,GFP)2Pgr/? [background:] involves: 129 * C57BL/6 * FVB/N * NMRI
  • abnormal eye development
  • abnormal retina bipolar cell morphology
MGI
E2f3tm1.1Gle/E2f3tm1.1Gle Rbl1tm1Htr/Rbl1tm1Htr Tg(Pax6-cre,GFP)2Pgr/? [background:] involves: 129 * C57BL/6 * FVB/N * NMRI
  • abnormal amacrine cell morphology
  • abnormal eye development
MGI
Rb1tm1Tyj/Rb1+ Rbl1tm1Tyj/Rbl1+ [background:] involves: 129S2/SvPas * C57BL/6
  • decreased tumor-free survival time
  • increased pituitary gland tumor incidence
MGI
Rb1tm1Tyj/Rb1+ Rbl1tm1Tyj/Rbl1tm1Tyj [background:] involves: 129S2/SvPas * C57BL/6
  • abnormal perineum morphology
  • abnormal retina morphology
MGI
Rb1tm1Tyj/Rb1tm1Tyj Rbl1tm1Mru/Rbl1tm1Mru [background:] involves: 129S2/SvPas * 129S4/SvJae * BALB/c * C57BL/6
  • increased neuronal precursor cell number
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
156.99M157.00M157.01M157.02M157.03M157.04M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions

No data available