Gene

Ptger4

Species
Mus musculus
Symbol
Ptger4
Name
prostaglandin E receptor 4 (subtype EP4)
Synonyms
  • EP4
  • prostaglandin E receptor EP4 subtype
Biotype
protein coding gene
Automated Description
Predicted to enable prostaglandin E receptor activity. Involved in several processes, including T-helper cell differentiation; cellular response to mechanical stimulus; and regulation of cytokine production. Acts upstream of or within several processes, including regulation of ossification; response to lipopolysaccharide; and response to nematode. Predicted to be located in neuron projection terminus; neuronal cell body; and nuclear membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including arterial system; central nervous system; genitourinary system; heart valve; and skin. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4).
MGI Description
PHENOTYPE: Most homozygous targeted null mutants die shortly after birth due to failed closure of the ductus arteriosis. Survivors show decreased migration of Langerhans cells to lymph nodes, contact hypersensitivity and decreased incidence of induced arthritis. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11866
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            5.263M5.264M5.265M5.266M5.267M5.268M5.269M5.270M5.271M5.272M5.273M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Ptger4 molecule type
            Interactor gene
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              Genetic Interactions

              Ptger4 role
              Ptger4 genetic perturbation
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