Version: 8.0.0Date: Tue Jan 28 2025
Gene
Hcls1
- Species
- Mus musculus
- Symbol
- Hcls1
- Name
- hematopoietic cell specific Lyn substrate 1
- Synonyms
- AW213261
- expressed sequence AW213261
- Biotype
- protein coding gene
- Automated Description
- Enables SH3 domain binding activity. Involved in several processes, including erythrocyte differentiation; positive regulation of myeloid leukocyte differentiation; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Orthologous to human HCLS1 (hematopoietic cell-specific Lyn substrate 1).
- MGI Description
- PHENOTYPE: Mice homozygous for disruptions in this gene show impaired antibody production to T-independent antigen and impaired proliferative responses of splenic B and T cells after cross-linking of antigen receptors. [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10829
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|
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Sequence Feature Viewer
- Genome location
- Chr16:36755345...36783574 + (28.23 kb)
- Assembly version
- GRCm39
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