Version: 8.0.0Date: Tue Jan 28 2025
Gene
Tnf
- Species
- Mus musculus
- Symbol
- Tnf
- Name
- tumor necrosis factor
- Synonyms
- DIF
- RATTNF
- Biotype
- protein coding gene
- Automated Description
- Enables protease binding activity; receptor ligand activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including macrophage activation; positive regulation of cell communication; and regulation of primary metabolic process. Acts upstream of or within several processes, including apoptotic signaling pathway; regulation of macromolecule metabolic process; and response to bacterium. Located in several cellular components, including external side of plasma membrane; phagocytic cup; and recycling endosome. Is active in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; integumental system; and lung. Used to study several diseases, including autoimmune disease (multiple); congestive heart failure; heart valve disease (multiple); idiopathic pulmonary fibrosis; and spondyloarthropathy. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); liver disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor).
- MGI Description
- PHENOTYPE: Mutations at this locus primarily affect the immune system, causing increased susceptibility to infection, failure to form splenic B-cell follicles, increased inflammation and impaired contact hypersensitivity. Homozygotes also may show metabolic defects. Combined deletions of certain regulatory regions in the 3' UTR are embryonic lethal (homozygous) or cause arthritis and intestinal and cardiac valve inflammation and reduced lifespan (heterozygous). [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11471
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr17:35418357...35420983 - (2.63 kb)
- Assembly version
- GRCm39
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.