Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryo implantation; positive regulation of stem cell population maintenance; and trophectodermal cell fate commitment. Located in cytoplasm. Part of protein-DNA complex and transcription regulator complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system gland; and skeletal musculature. Orthologous to human TEAD4 (TEA domain transcription factor 4).
MGI Description
PHENOTYPE: Mice homozygous for a null allele die prior to somitogenesis, lack trophoblast stem cells and develop abnormally. [provided by MGI curators]