Gene

Tead4

Species
Mus musculus
Symbol
Tead4
Name
TEA domain family member 4
Synonyms
  • ETFR-2a
  • Etfr2
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryo implantation; positive regulation of stem cell population maintenance; and trophectodermal cell fate commitment. Located in cytoplasm. Part of protein-DNA complex and transcription regulator complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system gland; and skeletal musculature. Orthologous to human TEAD4 (TEA domain transcription factor 4).
MGI Description
PHENOTYPE: Mice homozygous for a null allele die prior to somitogenesis, lack trophoblast stem cells and develop abnormally. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11834
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
128.21M128.22M128.23M128.24M128.25M128.26M128.27M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions