Gene

Irgm1

Species
Mus musculus
Symbol
Irgm1
Name
immunity-related GTPase family M member 1
Synonyms
  • Ifggd3
  • Ifi1
Biotype
protein coding gene
Automated Description
Enables GTPase activity and anion binding activity. Involved in several processes, including positive regulation of leukocyte activation; positive regulation of macroautophagy; and regulation of defense response. Acts upstream of or within cellular response to type II interferon and response to bacterium. Located in cytoplasmic vesicle and vacuole. Is active in Golgi membrane; lysosomal membrane; and mitochondrial membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit impaired cell-autonomous Toxoplasma killing. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR32341
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
48.757M48.758M48.759M48.760M48.761M48.762M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions