Gene

Kif3a

Species
Mus musculus
Symbol
Kif3a
Name
kinesin family member 3A
Synonyms
  • AF180004
  • AF180009
Biotype
protein coding gene
Automated Description
Enables intraciliary transport particle B binding activity and microtubule binding activity. Involved in several processes, including alpha-tubulin acetylation; anterograde dendritic transport of neurotransmitter receptor complex; and microtubule cytoskeleton organization. Acts upstream of or within several processes, including chordate embryonic development; plasma membrane bounded cell projection organization; and regionalization. Located in centriole; motile cilium; and photoreceptor connecting cilium. Part of kinesin II complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including gonad; liver; nervous system; node; and spleen. Used to study dysostosis; polycystic kidney disease; and polycystic kidney disease 1. Orthologous to human KIF3A (kinesin family member 3A).
MGI Description
PHENOTYPE: Nullizygous mutations result in embryonic lethality, failure to synthesize cilia in the embryonic node, randomization of left-right asymmetry and structural abnormalities of the neural tube, pericardium, branchial arches, and somites. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24115
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
53.460M53.465M53.470M53.475M53.480M53.485M53.490M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions