Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
---|---|---|---|---|---|
Homo sapiens | CASP4 | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
Homo sapiens | CASP5 | 9 of 10 | No | Yes | ☑☐☑☑☑☑☑☑☑☑ |
Rattus norvegicus | Casp4 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
Xenopus tropicalis | casp1 | 5 of 9 | Yes | Yes | ☑ ☐☐☑☑☐☑☑☐ |
Danio rerio | caspa | 9 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☐ |
Danio rerio | casp23 | 8 of 10 | No | Yes | ☑ ☑☑☐☑☑☑☑☑ ☐ |
Danio rerio | caspb | 7 of 10 | No | Yes | ☑ ☑☐☑☑☑☑☑☐ ☐ |
Danio rerio | caspbl | 6 of 10 | No | Yes | ☑ ☑☐☐☑☑☑☑☐ ☐ |
Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
---|---|---|---|---|---|---|
Casp12 | 1 | 425 | 56 | 40 | 8 of 9 | ☑☐☑☑☑☑☑☑☑ |
Casp1 | 2 | 404 | 56 | 42 | 7 of 9 | ☑☐☑☐☑☑☑☑☑ |
Casp2 | 3 | 443 | 44 | 26 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
Casp8 | 4 | 417 | 40 | 24 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
Casp9 | 5 | 404 | 37 | 25 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
Casp3 | 6 | 347 | 38 | 25 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
Casp14 | 7 | 286 | 42 | 26 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
Casp7 | 8 | 265 | 43 | 27 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
Casp6 | 9 | 284 | 40 | 24 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
Cflar | 10 | 291 | 38 | 21 | 3 of 9 | ☑☐☐☐☐☐☑☑☐ |
Casp16 | 11 | 2 of 9 | ☑☐☐☐☐☐☐☑☐ |
Phenotype Term | Annotation details | References |
---|---|---|
decreased circulating interleukin-1 alpha level | ||
decreased circulating interleukin-1 beta level | ||
decreased circulating interleukin-18 level | ||
decreased interleukin-1 alpha secretion | ||
decreased interleukin-1 beta secretion | ||
decreased interleukin-18 secretion | ||
decreased macrophage apoptosis | ||
decreased pulmonary ventilation | ||
decreased susceptibility to endotoxin shock | ||
decreased susceptibility to xenobiotic induced morbidity/mortality |
all annotations | all disease by infectious agent | bacterial infectious disease | fungal infectious disease | parasitic infectious disease | viral infectious disease | all disease of anatomical entity | cardiovascular system disease | central nervous system disease | endocrine system disease | gastrointestinal system disease | hematopoietic system disease | immune system disease | integumentary system disease | musculoskeletal system disease | peripheral nervous system disease | reproductive system disease | respiratory system disease | sensory system disease | thoracic disease | urinary system disease | all disease of cellular proliferation | benign neoplasm | cancer | pre-malignant neoplasm | all genetic disease | chromosomal disease | monogenic disease | polygenic disease | all other disease | disease of mental health | disease of metabolism | physical disorder | syndrome | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
---|---|---|---|---|---|---|---|---|
Homo sapiens | CASP5 | is marker for | Alzheimer's disease |
|
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
---|---|---|---|---|---|---|---|
Casp4tm1Vmd |
| allele | |||||
Casp4tm1c(KOMP)Wtsi | allele | ||||||
Casp4em5Gpt |
| allele | |||||
Casp4tm1Yuan |
| allele | Yes | ||||
Casp4tm1.1Vmd |
| allele | Yes | ||||
Casp4tm1a(KOMP)Wtsi | allele | ||||||
Casp4em1Cya |
| allele | |||||
Casp4tm1b(KOMP)Wtsi | allele | Yes | |||||
Casp4em1Gpt |
| allele | |||||
Casp4em2Cya |
| allele |
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
---|---|---|---|---|---|---|---|
Mus musculus | Tg(Casp4)#Gne |
Casp4 molecule type | Interactor gene | Interactor species | Interactor molecule type | Detection methods | Source | Reference |
---|---|---|---|---|---|---|
protein | GSDMD | Homo sapiens | protein |
| PMID:26375003 | |
protein | Gsdmd | Mus musculus | protein |
| PMID:26375259 |