Gene

Casp4

Species
Mus musculus
Symbol
Casp4
Name
caspase 4, apoptosis-related cysteine peptidase
Synonyms
  • capase 11, apoptosis-related cysteine protease
  • Casp11
Biotype
protein coding gene
Automated Description
Enables cysteine-type endopeptidase activity and lipopolysaccharide binding activity. Involved in several processes, including non-canonical inflammasome complex assembly; positive regulation of signal transduction; and response to bacterium. Acts upstream of or within ectopic germ cell programmed cell death; positive regulation of interleukin-1 beta production; and positive regulation of macrophage cytokine production. Part of non-canonical inflammasome complex. Is active in cytosol. Is expressed in several structures, including gut; lung; metanephros; reproductive system; and ureter. Orthologous to several human genes including CASP4 (caspase 4).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in decreased levels of serum IL-1alpha and IL-1beta. Mutant animals are resistant to septic shock after injection with LPS. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10454
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCASP410 of 10YesYes  
Homo sapiensCASP59 of 10NoYes  
Rattus norvegicusCasp49 of 9YesYes   
Xenopus tropicaliscasp15 of 9YesYes   
Danio reriocaspa9 of 10YesYes  
Danio reriocasp238 of 10NoYes  
Danio reriocaspb7 of 10NoYes  
Danio reriocaspbl6 of 10NoYes  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Casp12142556408 of 9 
Casp1240456427 of 9 
Casp2344344263 of 9 
Casp8441740243 of 9 
Casp9540437253 of 9 
Casp3634738253 of 9 
Casp14728642263 of 9 
Casp7826543273 of 9 
Casp6928440243 of 9 
Cflar1029138213 of 9 
Casp16112 of 9 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
decreased circulating interleukin-1 alpha level
decreased circulating interleukin-1 beta level
decreased circulating interleukin-18 level
decreased interleukin-1 alpha secretion
decreased interleukin-1 beta secretion
decreased interleukin-18 secretion
decreased macrophage apoptosis
decreased pulmonary ventilation
decreased susceptibility to endotoxin shock
decreased susceptibility to xenobiotic induced morbidity/mortality
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Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Homo sapiensCASP5
is marker forAlzheimer's disease
  • IEP
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    Alleles and Variants

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    5.310M5.315M5.320M5.325M5.330M5.335M
    Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    Casp4tm1Vmd
    • Casp11fl
    allele
    Casp4tm1c(KOMP)Wtsiallele
    Casp4em5Gpt
    • Casp4em5Cd3268
    allele
    Casp4tm1Yuan
    • casp-11
    • Casp11-
    allele
    Yes
    Casp4tm1.1Vmd
    • Casp4tm1.1Gne
    allele
    Yes
    Casp4tm1a(KOMP)Wtsiallele
    Casp4em1Cya
    • Casp4em1
    allele
    Casp4tm1b(KOMP)Wtsiallele
    Yes
    Casp4em1Gpt
    • Casp4em1Cflox
    allele
    Casp4em2Cya
    • Casp4em1flox
    allele
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    Transgenic Alleles

    Species
    (carrying the transgene)
    Allele symbol
    Transgenic construct
    Expressed components
    Knock-down targets
    Regulatory regions
    Has Disease Annotations
    Has Phenotype Annotations
    Mus musculusTg(Casp4)#Gne
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    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    Casp1tm1Sesh/Casp1tm1Sesh Casp4del/Casp4del [background:] NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ
    • decreased interleukin-1 alpha secretion
    • decreased interleukin-1 beta secretion
    MGI
    Casp1tm1Flv/Casp1tm1Flv Casp4del/Casp4del [background:] B6.129S2-Casp1tm1Flv
    • abnormal gut flora balance
    • decreased interleukin-1 beta secretion
    MGI
    Casp1tm1Flv/Casp1tm1Flv Casp4del/Casp4del [background:] involves: 129S2/SvPas
    • decreased metastatic potential
    • decreased susceptibility to induced morbidity/mortality
    MGI
    Casp1tm1Flv/Casp1tm1Flv Casp4del/Casp4del [background:] involves: 129S2/SvPas * C57BL/6
    • abnormal cytokine secretion
    • decreased circulating interferon-gamma level
    MGI
    Casp1tm1Flv/Casp1tm1Flv Casp4del/Casp4del [background:] involves: 129S2/SvPas * C57BL/6J
    • decreased incidence of tumors by chemical induction
    MGI
    Casp1tm1Flv/Casp1tm1Flv Casp4del/Casp4del Il1r1tm1Imx/Il1r1tm1Imx [background:] involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
    • decreased susceptibility to endotoxin shock
    MGI
    Casp1tm1Flv/Casp1tm1Flv Casp4del/Casp4del Slc11a1r/Slc11a1r [background:] involves: 129S2/SvPas
    • increased susceptibility to bacterial infection
    • increased susceptibility to induced morbidity/mortality
    MGI
    Casp1tm1Flv/Casp1tm1Flv Casp4del/Casp4del Slc11a1s/Slc11a1s [background:] B6.129S2-Casp1tm1Flv
    • cecum inflammation
    • increased susceptibility to bacterial infection
    MGI
    Casp1tm1Sesh/Casp1+ Casp4del/Casp4+ [background:] involves: 129S1/SvImJ * 129S2/SvPas * NOD
    • abnormal macrophage physiology
    MGI
    Casp1tm1Sesh/Casp1+ Casp4del/Casp4+ [background:] involves: 129S2/SvPas * C57BL/6
    • decreased interleukin-1 beta secretion
    MGI
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    5.310M5.315M5.320M5.325M5.330M5.335MENSMUST00000027012 (Casp4)ENSMUST00000159461 (Casp4)ENSMUST00000160064 (Casp4)ENSMUST00000162846 (Casp4)NM_001379318.1 (Casp4)NM_001379319.1 (Casp4)NM_001379320.1 (Casp4)NM_001379321.1 (Casp4)NM_001379322.1 (Casp4)NM_001379323.1 (Casp4)Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    2 interactor genes based on 2 annotations
    Casp4 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    GSDMDHomo sapiens
    protein
    • protease assay
    PMID:26375003
    protein
    GsdmdMus musculus
    protein
    • protease assay
    PMID:26375259
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    Genetic Interactions

    No data available