Acts upstream of or within negative regulation of protein kinase activity; positive regulation of MAPK cascade; and regulation of cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; embryo mesenchyme; future brain; hindlimb long bone; and sensory organ. Orthologous to human GADD45B (growth arrest and DNA damage inducible beta).
MGI Description
PHENOTYPE: Homozygous inactivation of this locus affects immune response. [provided by MGI curators]