Enables promoter-specific chromatin binding activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and negative regulation of peptidyl-serine phosphorylation of STAT protein. Acts upstream of or within centrosome cycle; negative regulation of protein kinase activity; and regulation of cell cycle. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; hindlimb; and sensory organ. Used to study systemic lupus erythematosus. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha).
MGI Description
PHENOTYPE: Homozygous null mice show genomic instability, thymus hyperplasia, elevated radiation carcinogenesis, abnormal parturition and low frequency exencephaly. Females develop a lupus-like syndrome associated with high titers of autoantibodies, hematologic deficits, glomerulonephritis and premature death. [provided by MGI curators]