Gene

Gadd45a

Species
Mus musculus
Symbol
Gadd45a
Name
growth arrest and DNA-damage-inducible 45 alpha
Synonyms
  • AA545191
  • Ddit1
Biotype
protein coding gene
Automated Description
Enables promoter-specific chromatin binding activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and negative regulation of peptidyl-serine phosphorylation of STAT protein. Acts upstream of or within centrosome cycle; negative regulation of protein kinase activity; and regulation of cell cycle. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; hindlimb; and sensory organ. Used to study systemic lupus erythematosus. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha).
MGI Description
PHENOTYPE: Homozygous null mice show genomic instability, thymus hyperplasia, elevated radiation carcinogenesis, abnormal parturition and low frequency exencephaly. Females develop a lupus-like syndrome associated with high titers of autoantibodies, hematologic deficits, glomerulonephritis and premature death. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10411
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
67.0122M67.0124M67.0126M67.0128M67.0130M67.0132M67.0134M67.0136M67.0138M67.0140M67.0142M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions