Predicted to enable identical protein binding activity. Involved in blood coagulation and megakaryocyte development. Predicted to be located in plasma membrane. Predicted to be part of glycoprotein Ib-IX-V complex. Is expressed in central nervous system; heart; male reproductive gland or organ; retina; and yolk sac. Used to study Bernard-Soulier syndrome. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome. Orthologous to human GP1BB (glycoprotein Ib platelet subunit beta).
MGI Description
PHENOTYPE: Mice homozygous for disruptions in this gene have a significantly smaller than normal number of abnormally large platelets. They also display a severe bleeding phenotype. [provided by MGI curators]