Predicted to enable RNA polymerase binding activity; histone deacetylase binding activity; and protein serine/threonine kinase activity. Involved in apical junction assembly. Located in apical junction complex; cytoplasm; and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human PKN2 (protein kinase N2).
MGI Description
PHENOTYPE: Mice homozygous for a null allele display embryonic lethality during organogenesis with impaired mesenchymal cell proliferation and neural crest cell migration.
[provided by MGI curators]