Version: 8.0.0
Date: Tue Jan 28 2025
Kcnab2
Mus musculusMGI:109239
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Kcnab2

Species
Mus musculus
Symbol
Kcnab2
Name
potassium voltage-gated channel, shaker-related subfamily, beta member 2
Synonyms
  • F5
  • I2rf5
Biotype
protein coding gene
Automated Description
Predicted to enable aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in neuromuscular process. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in axon terminus; juxtaparanode region of axon; and postsynaptic density. Is active in axon initial segment. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and sensory organ. Used to study chromosome 1p36 deletion syndrome. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2).
MGI Description
PHENOTYPE: Homozygous null mice show strain-specific changes in survival, body weight, thermoregulation and cold-swim induced tremors, impaired associative learning and memory, sporadic seizures and amygala hyperexcitability. Mice homozygous for a knock-in mutationshow no deficits in associative learning. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43150
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            152.48M152.49M152.50M152.51M152.52M152.53M152.54M152.55M152.56M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Kcnab2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              Kcnab2 role
              Kcnab2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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