Gene

Nnt

Species
Mus musculus
Symbol
Nnt
Name
nicotinamide nucleotide transhydrogenase
Synonyms
  • 4930423F13Rik
  • AI323702
Biotype
protein coding gene
Automated Description
Predicted to enable NADP binding activity. Predicted to be involved in several processes, including cell redox homeostasis; intracellular oxygen homeostasis; and positive regulation of hydrogen peroxide catabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; musculature; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase).
MGI Description
PHENOTYPE: Mutations in this gene cause impaired glucose tolerance and loss of both glucose-dependent insulin secretion and ATP production in isolated pancreatic islets. Also, beta cells from ENU-induced mutants show enhanced glucose utilization and production of reactive oxygen species in response to glucose. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10160
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
119.48M119.49M119.50M119.51M119.52M119.53M119.54M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions