Gene

Noct

Species
Mus musculus
Symbol
Noct
Name
nocturnin
Synonyms
  • AU043840
  • carbon catabolite repression 4 homolog (S. cerevisiae)
Biotype
protein coding gene
Automated Description
Enables mRNA binding activity and poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of fat cell differentiation; and regulation of gene expression. Acts upstream of or within P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body; nucleus; and perinuclear region of cytoplasm. Is expressed in 2-cell stage embryo; central nervous system; and retina. Orthologous to human NOCT (nocturnin).
MGI Description
PHENOTYPE: Mice homozygous for a null allele are resistant to diet-induced obesity and fatty liver development, show increased circulating glucose levels and increased insulin sensitivity on a standard diet and have impaired glucose tolerance on a high fat diet. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12121
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
51.135M51.140M51.145M51.150M51.155M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions