Gene

Trpc3

Species
Mus musculus
Symbol
Trpc3
Name
transient receptor potential cation channel, subfamily C, member 3
Synonyms
  • moonwalker
  • Mwk
Biotype
protein coding gene
Automated Description
Predicted to enable calcium-activated cation channel activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Predicted to be involved in several processes, including positive regulation of calcium ion transport into cytosol; positive regulation of cardiac muscle hypertrophy in response to stress; and response to ATP. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cochlea; ganglia; gonad; spinal cord; and trunk somite. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3).
MGI Description
PHENOTYPE: Homozygous knockout mice or mice heterozygoous for a point mutation in exon 7 display an abnormal gait. Abnormal nervous system electrophysiology is also described. An A1903G point mutation in exon 7 results in homozygous lethality. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10117
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
36.68M36.69M36.70M36.71M36.72M36.73M36.74M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions