Gene

Bmpr2

Species
Mus musculus
Symbol
Bmpr2
Name
bone morphogenetic protein receptor type 2
Synonyms
  • 2610024H22Rik
  • AL117858
Biotype
protein coding gene
Automated Description
Enables BMP binding activity and BMP receptor activity. Involved in several processes, including BMP signaling pathway; circulatory system development; and negative regulation of cell proliferation involved in heart valve morphogenesis. Acts upstream of or within several processes, including limb development; maternal placenta development; and mesoderm formation. Located in cell surface and postsynaptic density. Is active in several cellular components, including cell body; clathrin-coated pit; and dendrite. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo ectoderm; and genitourinary system. Used to study primary pulmonary hypertension. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease 1. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2).
MGI Description
PHENOTYPE: Homozygous null mutants arrest at the egg cylinder stage and die before embryonic day 9.5 with failure to form organized structure and lacking mesoderm. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23255
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
59.82M59.84M59.86M59.88M59.90M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions