Version: 8.0.0
Date: Tue Jan 28 2025
Slc2a2
Mus musculusMGI:1095438
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Slc2a2

Species
Mus musculus
Symbol
Slc2a2
Name
solute carrier family 2 (facilitated glucose transporter), member 2
Synonyms
  • AI266973
  • expressed sequence AI266973
Biotype
protein coding gene
Automated Description
Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in D-glucose transmembrane transport; dehydroascorbic acid transport; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in several cellular components, including apical plasma membrane; brush border; and cell-cell junction. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; immune system; and liver and biliary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Fanconi-Bickel syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2).
MGI Description
PHENOTYPE: Homozygous null mice are hyperglycemic with hypoinsulinemia and die within 2-3 weeks of life displaying increased plasma levels of glucagon, free fatty acids and beta-hydroxybutyrate, abnormal glucose tolerance, and altered postnatal development of pancreatic islets. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23503
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Slc2a2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Slc2a2 role
            Slc2a2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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